Wuhan Feiyue Biotechnology Co., LTD

Feiyue's Human  SESN3(Sestrin-3) ELISA Kit is an ELISA reagent for detection of SESN3(Sestrin-3) in human serum, plasma or cell with sensitivity, specificity and consistency.

SESN3(Sestrin-3) Introduction

Sestrin-3  is a protein that in humans is encoded by the SESN3 gene.This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

This kit uses sandwich ELISA to detect the concentration of SESN3(Sestrin-3). SESN3(Sestrin-3) ELISA Kit allows for the in vitro quantitative determination of SESN3(Sestrin-3) concentrations in serum, plasma, tissue homogenates and other biological fluids. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SESN3(Sestrin-3). 

Reference:

1，Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

2，Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N (2010). "FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor". Dev. Cell. 18 (4): 592–604. doi:10.1016/j.devcel.2010.03.008. PMC 3031984. PMID 20412774.

3，Zamkova M, Khromova N, Kopnin BP, Kopnin P (2013). "Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways". Cell Cycle. 12 (5): 826–36. doi:10.4161/cc.23723. PMC 3610730. PMID 23388456.

FAQ:

Q1. Is sample order available?
A: Yes, we welcome sample order to test and check quality.
Q2. What about the lead time?
A: Sample order: 3-5 days, mass order:10-12 days. The actual time depends on the order quantity.
Q3. Do you have any MOQ limit for led light order?
A: Low MOQ, 1pc for sample checking is available
Q4. How do you ship the goods and how many days will it take?
A: Our main shipping agent are DHL, FedEx, UPS and TNT, etc. It takes 3-7 days.
Q5. Is it OK to use my own package?
A: Yes. Normally we offer white inner box and carton box. Your own design is ok.

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