Wuhan Feiyue Biotechnology Co., LTD

Feiyue's Human RHOA(Transforming protein RhoA) ELISA Kit is an ELISA reagent for detection of RHOA(Alpha Crosslaps) in Mouse serum, plasma or cell with sensitivity, specificity and consistency.

Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene.[5] While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation. RhoA's physiological functions have been linked to the contraction and migration of cells which are manifested as symptoms in both asthma and diabetes (i.e. airflow limitation and hyper-responsiveness, desensitization, etc.). Due to pathophysiological overlap of RhoA and Rho-kinase in asthma, both RhoA and Rho-kinase have become promising new target molecules for pharmacological research to develop alternate forms of treatment for asthma. RhoA and Rho kinase mechanisms have been linked to diabetes due to the up-regulated expression of targets within type 1 and 2 diabetic animals. Inhibition of this pathway prevented and ameliorated pathologic changes in diabetic complications, indicating that RhoA pathway is a promising target for therapeutic development in diabetes treatment.

Human RHOA(Transforming protein RhoA) ELISA Kit Test method

This kit uses sandwich ELISA to detect the concentration of RHOA. RHOA ELISA Kit allows for the in vitro quantitative determination of RHOA concentrations in serum, plasma, tissue homogenates and other biological fluids. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RHOA. 

Reference:

1, Markers of bone resorption--measurement in serum, plasma or urine?

1, GRCh38: Ensembl release 89: ENSG00000067560 - Ensembl, May 2017

2,Jump up to:a b c GRCm38: Ensembl release 89: ENSMUSG00000007815 - Ensembl, May 2017

3, "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

FAQ:

Q1. Is sample order available?
A: Yes, we welcome sample order to test and check quality.
Q2. What about the lead time?
A: Sample order: 3-5 days, mass order:10-12 days. The actual time depends on the order quantity.
Q3. Do you have any MOQ limit for led light order?
A: Low MOQ, 1pc for sample checking is available
Q4. How do you ship the goods and how many days will it take?
A: Our main shipping agent are DHL, FedEx, UPS and TNT, etc. It takes 3-7 days.
Q5. Is it OK to use my own package?
A: Yes. Normally we offer white inner box and carton box. Your own design is ok.

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